Their friendship goes a long way and instead of rocking a once in a lifetime opportunity solo, 2 Chainz called on Lil’ Wayne at the 2012 MTV Video Music Awards. Opening up with the intro off his Based on a T.R.U. Story debut, Tity Boi rocked the crowd with “Yuck” as Lil’ Wayne joined the stage to perform his guest verse. Weezy ended their set by performing his new single off I Am Not A Human Being II, “No Worries” for the first-time ever. You can also download the cut off his Dedication 4 mixtape with DJ Drama.

Watch performances from 2 Chainz, Lil’ Wayne, Frank Ocean, Pink, One Direction, Green Day, and Taylor Swift after the jump…..

2 Chainz & Lil’ Wayne – “Yuck” & “No Worries”

Frank Ocean made his MTV Video Music Awards debut on Thursday night in Los Angeles. Surrounded by a nature like setting, the Odd Future crooner gave a live acoustic version of his channel, Orange single “Thinking About You.” Watch Frank serenade the millions watching, and thousands in attendance at Staples Center.

Pink – “Blow Me (One Last Kiss)”

One Direction – “One Thing”

Green Day – “Kill the DJ”

Related:
Lil’ Wayne, Nicki Minaj, 2 Chainz, ASAP Rocky to Perform at 2012 MTV VMAs
Rihanna, Drake, Beyoncé, Frank Ocean Lead 2012 MTV VMA Nominations

Previously (2011 MTV VMA’s Edition):
2011 MTV VMA Performances From Chris Brown, Adele, Lady Gaga & Lil’ Wayne (Videos)
Beyoncé Rubs Her Baby Belly at VMAs While Proud Papa Jay-Z Cheers (Video)
What Are They Wearing?! The 2011 VMA Red Carpet Live Blog
Odd Future at the 2011 MTV VMAs: Tyler The Creator Wins ‘Best New Artist,’ Frank Ocean Ignores Media
Rick Ross Claims Kreayshawn Is Cool But She Might Owe Khaled A Steak (Huh?)
Rick Ross Screams On Kreayshawn at the VMAs: A Beef Recap